2024 Slc40a1 macrophage

Slc40a1 macrophage

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August undefined, 2024

WebSep 13, 2024 · By comparing human and mouse, we have recently suggested a core gene signature specific to KCs (Table 1), including CD5L, VSIG4, CD163, FOLR2, MARCO, and … WebDec 28, 2024 · The glioblastoma microenvironment predominantly contains tumor-associated macrophages that support tumor growth and invasion. We investigated the relationship between tumor radiosensitivity and infiltrating M1/M2 macrophage profiles in public datasets of primary and recurrent glioblastoma. We estimated the radiosensitivity …

Anti-SLC40A1 Antibodies Invitrogen

WebIt has been reported that SLC40A1 mutations may lead to macrophage iron overload, hyperferritinemia, and normal transferrin saturation among ferroportin iron overload patients. This antibody detects 62-70 kDa protein as well as the fragments of 56 kDa and 35 kDa protein similar to papers in SDS-PAGE. (PMID: 21396368,16054062, 18974313) … WebBackgroundIt has been shown that tumor-associated immune cells, particularly macrophages, play a fundamental role in the development and treatment response of intrahepatic cholangiocarcinoma (ICC). However, little is known about macrophages at the single cellular level of ICC patients.MethodsScRNA-seq from Zhang et al. was used in the … midvale city business license

Mammalian iron transporters: Families SLC11 and SLC40

WebThe SLC40A1 gene is associated with autosomal dominant ferroportin disease (aka hemochromatosis type 4 (HFE4)) (MedGen UID: 340044). Providers. Providers Home. … WebApr 1, 2013 · Intestinal iron absorption is mediated by SLC11A2 at the apical membrane of enterocytes, followed by basolateral exit via SLC40A1. To meet the daily requirement for iron, approximately 80% of the iron comes from the breakdown of hemoglobin following macrophage phagocytosis of senescent erythrocytes (iron recycling). WebJun 28, 2024 · Ferroportin1 ( FPN1, SLC40A1) is the only known membrane protein that transports iron out of cells 2. It is highly expressed in cells involved in iron uptake, storage … midvale boys and girls club

F13A1 transglutaminase expression in human adipose tissue

SLC40A1 solute carrier family 40 member 1 - NIH Genetic Testing ...

WebSLC40A1 is an iron-regulated transporter assumed to play roles in intestinal iron absorption and cellular iron release. It mediates iron efflux in the presence of ferroxidase. Defects in … WebSep 13, 2024 · First, a population of liver capsule macrophages (LCMs) have been identified ( Sierro et al., 2024 ). The liver capsule consists of a single layer of mesothelial cells and a single stratum of capsular fibroblasts existing just beneath the … new tecumseth town hallWebMay 17, 2024 · We also revealed that a subset of macrophages expressing SLC40A1 and genes reacting to various infections was present in para-carcinoma but not in HCC tissue. These findings were independently validated with scRNA-Seq and large-scale tissue bulk RNA-Seq/microarray analyses. midvale city building department

"WebJan 24, 2024 · The major source of this iron is a recycling pathway where macrophages scavenge old and damaged erythrocytes to release iron contained within the heme moiety. Macrophages also promote erythropoiesis by providing a supportive niche in the bone marrow as an integral component of "erythorblastic islands." " - Slc40a1 macrophage

Slc40a1 macrophage

SLC40A1 Gene - GeneCards S40A1 Protein S40A1 …

WebOct 31, 2024 · Of the macrophages in tumors that exhibited distinct transcriptional states, tumor-associated macrophages (TAMs) were associated with poor prognosis, and we … WebSLC40A1. gene product. FPN1, HFE4, IREG1, MTP1, SLC11A3. The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal …

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WebApr 5, 2024 · Of the macrophages in tumors that exhibited distinct transcriptional states, tumor-associated macrophages (TAMs) were associated with poor prognosis, and we … WebOct 15, 2024 · In addition to binding sites for the general macrophage LDTFs PU.1 and C/EBPs, ... Slc40a1, C1qa, Acp5, and P2ry13 (Figures 5 F and S5 B). A similar effect of DLL4 was also observed in BM monocytes, in which 90 KC identity genes were induced by DLL4 stimulation for 48 h (Figure S5 C). Collectively, these findings indicate that DLL4 is …

WebIron overloading disorders linked to mutations in ferroportin have diverse phenotypes in vivo, and the effects of mutations on ferroportin in vitro range from loss of function (LOF) to gain of function (GOF) with hepcidin resistance. We reviewed 359 patients with 60 ferroportin variants. Overall, macrophage iron overload and low/normal transferrin saturation (TSAT) … WebIt is known that ferroportin (SLC40A1) gene is expressed at a low level in infertile women. Its mRNA levels were discovered to be down-regulated in these women, specifically in granulosa cells. What's more, low expression of ferroportin is also associated with infertility when some features like age and smoking habits are considered.

WebFerroportin is a 12-transmembrane domain protein, belonging to the major facilitator superfamily of transporters of small molecules, that is localized to the plasma membrane.Human Ferroportin has a theoretical molecular … WebFeb 9, 2024 · Quantification of monocytes and macrophages revealed that clusters CD52 mono, IRF1 mono, SERPINB2 mono, C1QC macro, and SLC40A1 macro were expanded in liver tissues and PBMCs of patients with alcoholic cirrhotic livers (P < 0.05) ( Figures 2B, E ).

WebMar 21, 2024 · SLC40A1 (Solute Carrier Family 40 Member 1) is a Protein Coding gene. Diseases associated with SLC40A1 include Hemochromatosis, Type 4 and Hemochromatosis, Type 1 . Among its related pathways are …

WebMacrophages of the reticuloendothelial system; Adipocytes; Role in development. Ferroportin-1 plays an important role in neural tube closure and forebrain patterning. … midvale city corporationWebMar 9, 2024 · Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 [ (house mouse)] Gene ID: 53945, updated on 9-Mar-2024. Summary. Enables ferrous iron … midvalecity.orgWebMar 10, 2011 · Patients with ferroportin iron overload due to loss-of-function mutations in SLC40A1 have macrophage iron overload, hyperferritinemia, and normal transferrin … new tecumseth vote resultsWebFerroportin (SLC40A1) is an iron transporter postulated to play roles in intestinal iron absorption and cellular iron release. Hepcidin, a regulatory peptide, binds to ferroportin … midvale city waterWebNational Center for Biotechnology Information new tecumseth virtual town hallWebFeb 7, 2024 · SLC40A1 solute carrier family 40 member 1. SLC40A1. solute carrier family 40 member 1. Gene ID: 30061, updated on 7-Feb-2024. Gene type: protein coding. Also … midvale early childhood centerWebDuring elevated serum iron levels, liver-derived hepcidin/HAMP negatively regulates cell surface ferroportin/SLC40A1 by inducing its ubiquitination, internalization, and degradation. Indeed, hepcidin/HAMP affinity towards ferroportin/SLC40A1 increases by 80-fold in the presence of iron. 1 publication Features Showing features for binding site. midvale city fire department