Ogg1 and inflammation
WebbHere we set out to investigate whether OGG1 contributes to inflammation in AP. Using the OGG1 inhibitor TH5487, we found that the drug suppressed acinar injury and … Webb9 maj 2024 · Aside from its function in DNA damage repairment, it has been reported that OGG1 takes part in the regulation of gene expression, derived from its DNA binding characteristic, and showed impacts on inflammation. Researchers believe that OGG1 could be the potential therapy target for relative disease.
Ogg1 and inflammation
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Webb20 nov. 2024 · A newly discovered OGG1 inhibitor has been found to decrease lung inflammation in mice and could in future treat acute respiratory distress syndrome (ARDS), sepsis and autoimmune diseases. The six-year study, by an international team of researchers, is published in Science. WebbDespite the lack of experimental proof that rodent cells have such nuclear and mitochondrial versions of OGG1, a significant increase of 8-oxo-dG in mitochondrial DNA compared to nuclear DNA has been reported in the liver of OGG1-deficient mutant mice, therefore indicating that OGG1 plays a significant role in the recovery of oxidative …
Webb13 apr. 2024 · The THP-1 cells, macrophages, and foam cells were detected, and CD36, CD11b and CCR2 (macrophages) and CD14 and CD41 (MPAs) were measured. The levels of inflammatory factors, lipoprotein, and mitogen-activated protein kinase (MAPK, p38) and phosphoInositide-3 Kinase (PI3K)/Akt(protein kinase B, PKB)-NF-κB … Webb14 jan. 2024 · Consistent with this observation, Ogg1-/- mice were significantly more sensitive to intestinal inflammation induced by acute exposure to dextran sulfate sodium. Taken together, these data indicate that in addition to their proclivity to obesity and metabolic disease, Ogg1-/- mice are prone to colonic inflammation.
Webb8 apr. 2024 · The study reveals that SopF can attenuate intestinal inflammation and suppress IECs expulsion to promote bacterial dissemination in mice infected with S. Typhimurium. The mechanism employed by SopF involves activating phosphoinositide-dependent protein kinase-1 (PDK1) to phosphorylate p90 ribosomal S6 kinase (RSK), … Webbmetabolic disease, Ogg1-/-mice are prone to colonic inflammation. Further, these data point to alterations in the intestinal microbiome as potential mediators of the metabolic and intesti-nal inflammatory response in Ogg1-/-mice. Introduction Oxidative stress can result from endogenous and exogenous generation of reactive oxygen spe-
Webb16 nov. 2024 · It was when developing a new molecule for inhibiting the enzyme that repairs oxygen damage to DNA that the researchers found, to their surprise, that it also dampened inflammation. It turned out that the enzyme OGG1, apart from repairing DNA, also triggers inflammation. The inhibitor blocks the release of inflammatory proteins, …
Webb16 nov. 2024 · Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflammation. the bull east farleigh for saleWebb20 juli 2024 · All tested oxidative stress inducers increased intracellular OGG1 levels, whereas only nicotine and 4-NQO induced NFE2L2/NRF2 levels. Nicotine, 4-NQO, and their combinational applications with Pg LPS induced the secretions of IL-1β and IL-1Ra, while that of IL-8 was inhibited by the presence of Pg LPS. tasmanian wedge-tailed eagle threatshttp://www.thailandmedical.news/news/enzyme-ogg1-inhibitor,-the-new-inflammation-inhibitor-discovered. the bull earlswood menuWebb30 dec. 2024 · OGG1 is primarily located in the cytoplasm and can enter the nucleus and mitochondria to repair damaged DNA or to exert epigenetic regulation of gene transcription. OGG1 is involved in a wide range of physiological processes, such as DNA repair, oxidative stress, inflammation, fibrosis, and autophagy. tasmanian wedge tailed eaglesWebb24 sep. 2024 · OGG1 (oxoguanisine glycolase 1) is a DNA repair enzyme in the base excision repair (BER) pathway that excises and repairs 8-OH-dG DNA lesions ( 11 ). A single nucleotide polymorphism (SNP) in OGG1 … tasmanian welcome to countryWebb@article{Hussain2024MitochondrialOE, title={Mitochondrial OGG1 expression reduces age-associated neuroinflammation by regulating cytosolic mitochondrial DNA.}, author={Mansoor Hussain and Xixia Chu and Burcin Duan Sahbaz and Samuel Gray and Komal Pekhale and Jae-Hyeon Park and Deborah L. Croteau and Vilhelm A. Bohr}, … tasmanian weather in aprilWebb14 jan. 2024 · Ogg1-/-mice have elevated plasma levels of pro-inflammatory cytokines. To determine if the elevated markers of intestinal inflammation were accompanied by … the bull east sussex