WebThese results suggest that Prx functions as a protector of ESC stemness by opposing ROS/JNK cascades during neurogenesis. Therefore, our findings have important implications for understanding of maintenance of ESC stemness through involvement of antioxidant enzymes and may lead to development of an alternative stem cell-based … WebHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer exhibits early relapses, poor prognoses, and high recurrence rates. Herein, a JNK-targeting compound has been developed that may be of utility in HER2-positive mammary carcinoma. The design of a pyrimidine-and coumarin-linked structure targeting JNK was explored and …
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WebActivated RAF is capable of phosphorylating MEK, and subsequently, the ERK/MAPK signaling pathway. After activation of ERK, ERK1/2 moves to the cytoplasm and nucleus … Web1 aug. 2005 · To correlate ROS production with RANKL responses, including MAP kinase activation and osteoclast differentiation, we first tested whether H 2 O 2 alone activates … butterfly literacy activity
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Web1 apr. 2006 · Role of IKK, JNK, and ROS in TNF- - induced cell death and proliferation. Soluble TNF- (sTNF) binds to TNF-R1, whereas membrane TNF- (mTNF) predominantly … Web1 jan. 2005 · JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation … Web13 apr. 2024 · Background: Papain possesses a potential anti-atherosclerosis (AS) effect.This study aimed to explore the inhibitory effects of papain on the monocyte-platelet aggregates (MPAs)-mediated production of foam cells in vitro and AS in vivo.. Research design and methods: THP-1 cells were induced or treated by platelet, papain, nuclear … ceawen